sGC activation in pulmonary hypertension
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Ardeschir Ghofrani; Friedrich Grimminger
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Article
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2005
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BioMed Central
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English
β 185 KB
Impairments of the NO-sGC-cGMP pathway provoke acute and chronic vascular injury, including endothelial dysfunction, vasoconstriction and vascular remodeling in the pulmonary circulation. We evaluated the effects of the novel sGC activator Bay 41-2272 in three different models of acute and chronic p