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Sexual dimorphic role of estrogen receptor-α (ER-α) gene expression in the regulation of reproductive and aggressive behaviors in mice

✍ Scribed by Sonoko Ogawa

Book ID
117364442
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
102 KB
Volume
31
Category
Article
ISSN
0168-0102

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The role of insulin-like growth factor-I (IGF-I) in regulating estrogen receptor-␣ (ER-␣) gene expression and activity was investigated in the human breast cancer cell line MCF-7. Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-␣ protein concentration by 3 h, and the amount o