Sex–dependent rearrangements resulting in CMT1A and HNPP
✍ Scribed by Lopes, Judith; Vandenberghe, Antoon; Tardieu, Sandrine; lonasescu, Victor; Lévy, Nicolas; Wood, Nicholas; Tachi, Nobutada; Bouche, Pierre; Latour, Philippe; Brice, Alexis
- Book ID
- 109918321
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 229 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1061-4036
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## Charcot -Marie-Tooth (CMT) disease type 1A is an inherited peripheral neuropathy characterized by slowly progressive distal muscle wasting and weakness, decreased nerve conduction velocities, and genetic linkage to 17p12. Most (>98%) CMT1A cases are caused by a DNA duplication of a 1.5-Mb regio
## Abstract Telomeres play a vital role in protecting the ends of chromosomes and preventing chromosome fusion. The failure of cancer cells to properly maintain telomeres can be an important source of the chromosome instability involved in cancer cell progression. Telomere loss results in sister ch