The pharmacokinetics of valproic acid (VPA) was investigated in six healthy volunteers. This was done by monitoring total and free (unbound) valproic acid levels in the serum, and the amount of one of its metabolites, VPA glucuronide, in the urine as a function of time, after a single dose administr
Sex related differences on valproic acid pharmacokinetics after oral single dose
✍ Scribed by Ibarra, Manuel; Vázquez, Marta; Fagiolino, Pietro; Derendorf, Hartmut
- Book ID
- 120485723
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 551 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1573-8744
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Furosemide solution was orally administered to 21 healthy adult males to determine dose proportionality over the dose range used and the reproducibility of disposition following a repeated dose. Furosemide solution was given in doses of 20,40, and 80mg, with the 40 mg dose repeated once. Blood was c
Twelve healthy children in three age groups anaesthetized for minor surgery were given a single oral dose of tiaprofenic acid (3 mg.kg-1) (TA). Seven blood samples and zero to 8 and 8 to 24 h urines were collected. TA concentrations in plasma and urine were measured by HPLC. No significant differenc