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Sex, MHC and complement C4 in autoimmune diseases

โœ Scribed by C. Yung Yu; Caroline C. Whitacre


Book ID
116577616
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
132 KB
Volume
25
Category
Article
ISSN
1471-4906

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The gene responsible for the lpr mutation in MRL mice that are prone to systemic lupus erythematosus has been shown to encode the apoptosis-inducing Fas antigen, thus pointing to control of apoptosis as a major regulatory mechanism in autoimmunity. In the non-obese diabetic mouse model for insulin-d