Sex hormones in postmenopausal women with primary biliary cirrhosis

✍ Scribed by Ulrik Becker; Thomas Almdal; Erik Christensen; Christian Gluud; Stense Farholt; Paul Bennett; Birgit Svenstrup; Finn Hardt

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 508 KB
• Volume: 13
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840130511

✦ Synopsis

To evaluate serum sex hormone profiles in nonalcoholic postmenopausal women with liver disease, 25 women with primary biliary cirrhosis (11 in cirrhotic stage) and 46 healthy controls were studied.

The patients had significantly (p < 0.05) elevated serum concentrations of estrone and androstenedione and significantly (p < 0.05) lower concentrations of estrone sulfate, dehydroepiandrosterone sulfate and 5a-dihydrotestosterone compared with the 46 controls. Serum concentrations of sex hormone binding globulin, testosterone, non-sex hormone binding globulin-bound testosterone and non-protein-bound testosterone did not differ significantly (p > 0.05) between primary biliary cirrhosis patients and controls. Patients in the cirrhotic stage had significantly (p < 0.05) higher concentrations of sex hormone binding globulin than did controls.

Patients in the cirrhotic stage had significantly (p < 0.05) higher sex hormone binding globulin and estrone sulfate levels compared with noncirrhotic patients with primary biliary cirrhosis. Otherwise, no significant differences were observed between cirrhotic and noncirrhotic patients.

The observed changes in steroid concentrations may be a consequence of hepatic dysfunction. (HEPATOLOGY 1991; 13:865-869.)

The liver is a sex hormone-responsive organ, and significant changes in hepatic functions are observed during pregnancy and treatment with sex hormones Endocrine disturbances are frequent in patients with chronic liver disease (4-9). In women with alcoholic liver disease, one clinical disturbance is early menopause (8,lO). Changes in sex hormone concentrations are seen in postmenopausal women with chronic alcoholic (11, 12) and nonalcoholic liver disease (13-16). Whether (1-3).