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Sex differences in the kinetic constants for the n-demethylation of ethylmorphine by rat liver microsomes

โœ Scribed by Donald S. Davies; Philippe L. Gigon; James R. Gillette


Book ID
115769708
Publisher
Elsevier Science
Year
1968
Tongue
English
Weight
585 KB
Volume
17
Category
Article
ISSN
0006-2952

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The possible interaction of pirenzepine with the mixed-function oxidases obtained from phenobarbital-pretreated rabbit microsomes was examined in vitro. Under experimental conditions that did not lead to its own N-demethylation, the drug inhibited the microsomal oxidase systems responsible for the N