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Sex differences in the effects of 17β-estradiol on vascular adrenergic responses

✍ Scribed by Angel L. García-Villalón; John N. Buchholz; Diana N. Krause; Sue P. Duckles

Book ID
117098753
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
609 KB
Volume
314
Category
Article
ISSN
0014-2999

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The nigrostriatal dopamine (DA) system is sexually dimorphic. In female but not male rats, striatal DA activity is modulated by gonadal steroid hormones. Ovariectomy (OVX) decreases striatal DA release and turnover. Estrogen replacement restores the response to that of the intact female in estrus. I