Sex differences in long-term gonadectomized rats: monoamine levels and [3H]nitroimipramine binding in brain nuclei

✍ Scribed by K. J. Renner; A. Biegon; V. N. Luine

• Book ID: 104677823
• Publisher: Springer-Verlag
• Year: 1985
• Tongue: English
• Weight: 304 KB
• Volume: 58
• Category: Article
• ISSN: 0014-4819
• DOI: 10.1007/bf00238968

✦ Synopsis

The levels of norepinephrine, dopamine, serotonin and the serotonin metabolite 5-hydroxyindoleacetic acid were measured in microdissected brain nuclei from long-term gonadectomized male and female rats. Females had 50 and 120% higher levels of serotonin in the anterior hypothalamic nucleus (AH) and arcuate-median eminence (AR-ME), respectively. No significant differences in norepinephrine, dopamine or 5-hydroxyindoline acetic acid were found in any of the brain nuclei sampled. The differences in serotonin content do not appear to result from a sexually dimorphic distribution of serotonin nerve terminals since quantitative autoradiography of 3H-nitroimipramine revealed no differences in binding between the sexes in the AH or AR-ME.