Sex differences in human urinary steroid metabolic profiles determined by gas chromatography

✍ Scribed by C.D. Pfaffenberger; E.C. Horning

• Book ID: 102984069
• Publisher: Elsevier Science
• Year: 1977
• Tongue: English
• Weight: 882 KB
• Volume: 80
• Category: Article
• ISSN: 0003-2697
• DOI: 10.1016/0003-2697(77)90654-6

✦ Synopsis

Fifty-two 24-hr urine collections from healthy male and female adults were analyzed by a new gas chromatographic method. High-resolution open tubular glass capillary columns with a coating of SE-30 liquid phase containing a dispersion of small particles of silanized silicic acid (Silanox) were employed. The components were analyzed as methoxime-trimethylsilyl ether derivatives. Seventeen urinary steroid metabolites were quantified through use of an internal reference compound. The results are interpreted as delineating two different types of steroid metabolism for premenopausal females: one group displays metabolic profiles closely resembling those of males. The biologic origin of this effect is not known, but it may be due to either late fetal or neonatal hormonal effects.