Sex Differences in Heart Disease

✍ Scribed by Bohuslav Ostadal, Naranjan S. Dhalla

• Publisher: Springer International Publishing;Springer
• Year: 2020
• Tongue: English
• Leaves: 287
• Series: Advances in Biochemistry in Health and Disease 21
• Edition: 1st ed.
• Category: Library

✦ Synopsis

Cardiovascular diseases are the leading cause of mortality in men and women. Unfortunately, women have traditionally been excluded from clinical trials, and female animals have been used less or sex was not reported in basic research studies. Until recently, consideration of both sexes was not required in clinical and preclinical studies focusing on cardiovascular diseases. However, the number of clinical and experimental papers dealing with sex differences and heart disease significantly increases during the last years. This trend is obviously the result of at least two facts: the number of examples of different behavior of the male and female heart under physiological and pathological conditions is steadily increasing and there were controversial reports on the beneficial and adverse effect of hormonal replacement therapy. Detailed molecular and cellular mechanisms of these differences are still unknown but one is clear already today: sex differences are so important that they should be considered by the selection of optimum diagnostic and therapeutic procedures in clinical practice.
The book presents 16 manuscripts on sex differences of heart disease, as developed by several investigators; the volume is organized in four parts. Part I, dealing with sex differences in cardiac ischemic injury, includes 5 chapters on experimental aspects of cardiac ischemia/reperfusion injury, the role of testosterone, and clinical aspects of ischemic heart disease. Part II is devoted to sex differences in heart failure and includes four chapters. Discussion in this part of the book is centered around the sex differences in heart failure due to volume overload. Part III of this volume includes four papers on risk factors of cardiovascular diseases, namely hypertension and obesity, and, finally, three chapters in part IV deal with sex differences of cardiac mitochondria under different pathological conditions. We believe this book will be very useful for cardiovascular scientists, graduate students, postdoctoral fellows and other health professionals.

✦ Table of Contents

Front Matter ....Pages i-xvi
Front Matter ....Pages 1-1
Gender-Related Differences in the Pathogenesis and Diagnosis of Ischemic Heart Disease (Marwan Saad, Michael Megaly, Franco Romeo, Jawahar L. Mehta)....Pages 3-23
Sex Differences in Cardiac Ischemia/Reperfusion Injury (Bohuslav Ostadal, Petr Ostadal, Jan Neckar)....Pages 25-37
The Roles of Testosterone in Cardiac Ischemia/Reperfusion Injury (Nattayaporn Apaijai, Siriporn C. Chattipakorn, Nipon Chattipakorn)....Pages 39-65
The Influence of Sex and Age on Responses of Isolated Ventricular Myocytes to Simulated Ischemia and Reperfusion (David G. Sapp, Susan E. Howlett)....Pages 67-85
Non-atherosclerotic Acute Cardiac Events in Young Women (Fabiola B. Sozzi, Marco Schiavone, Marta Belmonte)....Pages 87-107
Front Matter ....Pages 109-109
Sex Differences in Contractile Function in Cardiac Hypertrophy and Heart Failure Subsequent to Volume Overload (Paramjit S. Tappia, Anureet K. Shah, Mohamad Nusier, Naranjan S. Dhalla)....Pages 111-127
Sex-Specific Differences of Apoptosis in Heart Failure Due to Volume-Overload (Sukhwinder K. Bhullar, Anureet K. Shah, Naranjan S. Dhalla)....Pages 129-145
Sex-Specific Differences in β-Adrenoceptor Signal Transduction in Heart Failure Due to Volume-Overload (Naranjan S. Dhalla, Vijayan Elimban, Anureet K. Shah, Mohamad Nusier)....Pages 147-158
Sex and Heart Transplantation (Ana Ayesta, Manuel Martínez-Sellés)....Pages 159-175
Front Matter ....Pages 177-177
Sex, Age and Gene Interactions in Cardiometabolic Diseases (Pavel Hamet, Candan Hizel, Johanne Tremblay)....Pages 179-190
Sex Differences in Response to Fatty Acids in Cardiovascular Health and Disease (Paramjit S. Tappia, Anureet K. Shah)....Pages 191-202
Nutritional Aspect of Sex-Dependent Difference in Heart Disease (Anureet K. Shah, Anabela Kim, Carrie Adase)....Pages 203-216
Cardio-Oncology: Preventing Broken Hearts in Women with Breast Cancer (Hilary Bews, Cameron Eekhoudt, Sonu Varghese, Davinder S. Jassal)....Pages 217-236
Front Matter ....Pages 237-237
Sex-Related Pathophysiological Differences in Cardiac Mitochondria: Role of Estrogens (Natalia Pavón, Francisco Correa-Segura, Elizabeth Lira-Silva, Alfredo Cabrera-Orefice)....Pages 239-256
Cardiac Mitochondria and Ischemia/Reperfusion Injury—Sex Differences (Zdenek Drahota, Marketa Hlavackova, Bohuslav Ostadal)....Pages 257-265
Sex Differences in Mitochondrial Antioxidant Gene Expression (Consuelo Borrás, Cristina Mas-Bargues, Ana B. Paes, Susana Novella)....Pages 267-284

✦ Subjects

Life Sciences; Cardiovascular Biology