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Sex differences in cell death

โœ Scribed by Hong Li; Scott Pin; Zhiyuan Zeng; Michael M. Wang; Katrin A. Andreasson; Louise D. McCullough


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
88 KB
Volume
58
Category
Article
ISSN
0364-5134

No coin nor oath required. For personal study only.

โœฆ Synopsis


Abstract

Female patients experience substantial neuroprotection after experimental stroke compared with male patients, a finding attributed to the protective effects of gonadal hormones. This study examined the response of maleโ€ and femaleโ€derived organotypic hippocampal slices to oxidative and excitotoxic injury. Both oxygen and glucose deprivation and Nโ€methylโ€Dโ€aspartic acid exposure led to neuronal death; however, femaleโ€derived cultures sustained less injury than maleโ€derived cultures. Cell death after oxygen and glucose deprivation was ameliorated in male cultures, but not female cultures, by the addition of 7โ€nitroindazole, a neuronal nitric oxide synthase inhibitor. These studies have relevance to researchers investigating neuroprotective agents in mixed sex experiments. Ann Neurol 2005


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