Only male zebra finches sing, and acts on some HVC neurons before they complete their several brain regions implicated in song behavior exmigration and/or early differentiation. Although the hibit marked sex differences in neuron number. In one migratory route of HVC neurons is not known, a large re
Sex differences in cell death
โ Scribed by Hong Li; Scott Pin; Zhiyuan Zeng; Michael M. Wang; Katrin A. Andreasson; Louise D. McCullough
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 88 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
Female patients experience substantial neuroprotection after experimental stroke compared with male patients, a finding attributed to the protective effects of gonadal hormones. This study examined the response of maleโ and femaleโderived organotypic hippocampal slices to oxidative and excitotoxic injury. Both oxygen and glucose deprivation and NโmethylโDโaspartic acid exposure led to neuronal death; however, femaleโderived cultures sustained less injury than maleโderived cultures. Cell death after oxygen and glucose deprivation was ameliorated in male cultures, but not female cultures, by the addition of 7โnitroindazole, a neuronal nitric oxide synthase inhibitor. These studies have relevance to researchers investigating neuroprotective agents in mixed sex experiments. Ann Neurol 2005
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