Correlation studies between cytokines expressed in islets and autoimmune diabetes development in NOD mice and BB rats have demonstrated that -cell destructive insulitis is associated with increased expression of proinflammatory cytokines (IL-1, TNF␣, and IFN␣) and type 1 cytokines (IFN␥, TNF, IL-2
Sex difference in the incidence of insulin-dependent diabetes mellitus: an analysis of the recent epidemiological data
✍ Scribed by Karvonen, Marjatta ;Pitkäniemi, Maaria ;Pitkäniemi, Janne ;Kohtamäki, Kimmo ;Tajima, Naoko ;Tuomilehto, Jaakko
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 144 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0742-4221
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✦ Synopsis
Insulin-dependent diabetes mellitus (IDDM) is one of the major non-communicable diseases in children aged 14 years or under. Although the aetiology of IDDM is still unknown, it is currently assumed that both genetic 1-4 and environmental factors [5][6][7][8][9][10][11][12][13][14][15][16] operate together in a process in the pancreatic -cells leading to the onset of diabetes. Most of the information on IDDM incidence comes from the geographical regions with a high or intermediate level of incidence, e.g. Europe and North America, where a large number of IDDM registries have been established since the mid-1980s. Although several standardized registries have recently
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