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Sex-dependent sensitivity to dapsone-induced methaemoglobinaemia in the rat

✍ Scribed by M.D. Coleman; M.J. Winn; A.M. Breckenridge; B.K. Park

Book ID
115781455
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
601 KB
Volume
39
Category
Article
ISSN
0006-2952

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The administration of the GABA-blocking agents picrotoxin and bicuculline to adult (2.5-3 months old) CBA/HZgr mice resulted in the appearance of convulsions, the occurrence and/or lethality of which was greater in males than in females. The latency of picrotoxin-induced convulsions was also shorter