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Sex chromosome mosaicism in man

โœ Scribed by Hayward, M D

Book ID
109856205
Publisher
Nature Publishing Group
Year
1960
Tongue
English
Weight
80 KB
Volume
15
Category
Article
ISSN
0018-067X

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## Abstract Familial mosaicism has rarely been reported either for autosomes or sex chromosomes. Its recognition poses problems in prognosis, especially in prenatal diagnosis. Three generations of females showed sex chromosomal mosaicism with 3โ€“4 cell lines, the diploid predominant. Phenotypic effe

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Clinical and cytogenetic findings in three patients mosaic for sex chromosomes (45,X0/46,XY; 45,X0/46,XY/46,XYq-, and 45,X0/46,XY/46,XYY), each with a nonfluorescent Y, are presented. Hypotheses for the origin and effect of these chromosome constitutions are discussed.