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Severe tumor lysis syndrome following splenic irradiation

โœ Scribed by Schifter, Theodor; Cohen, Amos; Lewinski, Uri H.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
16 KB
Volume
60
Category
Article
ISSN
0361-8609

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โœฆ Synopsis

A 72-year-old man suffering from non-Hodgkin's lymphoma is described. After failing to respond to chlorambucil-prednisone regimen for three months, he was treated by splenic irradiation (total dose 500 cGY) in 10 consecutive daily doses. Two days after the last irradiation, the patient developed acute tumor lysis syndrome (TLS) with extreme blood levels of uric acid (33.7 mg/dl), phosphorus (13.7 mg/dl), potassium (6.08 mEq/l), and calcium (6.8 mg/dl). It should be remembered that the acute TLS, which usually occurs following chemotherapy, can also be radiation-induced. Am.

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