Severe sepsis induces deficient interferon-gamma and interleukin-12 production, but interleukin-12 therapy improves survival in peritonitis

Interferon-β therapy for multiple sclero

Interferon-β therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and interleukin-10 production

✍ Adriana A. Byrnes; Justin C. McArthur; Christopher L. Karp 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 178 KB 👁 1 views

## Abstract Interleukin–12 is critical to the pathogenesis of experimental autoimmune encephalomyelitis in multiple species. Interleukin‐10, a dominant endogenous inhibitor of interleukin‐12, is largely protective in these experimental surrogates for multiple sclerosis. Such data have suggested tha