Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
✍ Scribed by Fariñas, Isabel; Jones, Kevin R.; Backus, Carey; Wang, Xiao-Yun; Reichardt, Louis F.
- Book ID
- 109788932
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 631 KB
- Volume
- 369
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/369658a0
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📜 SIMILAR VOLUMES
Neurotrophins are a family of structurally and functionally related proteins that regulate neuronal survival during development. In the peripheral nervous system (PNS), both in vitro and in vivo studies have shown that neurotrophins are potent factors for the survival of various sensory neurons and
Neurotrophin-3 (NT3) is essential for development of sensory innervation to the skin. NT3 supports the postnatal survival of primary sensory neurons that mediate mechanoreception and their Merkel cell containing touch dome end organs (Airaksinen et al., 1996). In this study we determined whether NT3