Severe iron poisoning treated with enteral and intravenous deferoxamine
β Scribed by Fred M. Henretig; Stephen R. Karl; William H. Weintraub
- Book ID
- 104312554
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 401 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1097-6760
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β¦ Synopsis
An 18-month-old boy ingested approximately 18 g FGS04, equivalent to 336 mg/kg elemental Fe. He rapidly developed severe gastroenteric symptoms, obtundation, and transient hypotension. The serum iron level two hours after ingestion was 6,798 ~g/dL. He was treated with deferoxamine intravenously, enterally, and as a lavage solution. His hospital course was notable for lack of severe neurologic, hepatic, metabolic, or cardiovascular complications acutely with apparent complete recovery, although he returned six weeks after ingestion with intestinal obstruction due to a jejunal stricture.
π SIMILAR VOLUMES
Ten children with transfusion dependent anemias (thalassemia, sideroblastic anemia, congenital pure red cell aplasia) received either intravenous desferrioxamine (DF) in increasing doses up to 450 mg/kg at the time of transfusion or daily subcutaneous DF up to ll0mg/kg on an outpatient basis. No pat