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Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the Hepatocyte Nuclear Factor-1β gene

✍ Scribed by Simon C. Waller; Lesley Rees; Adrian S. Woolf; Sian Ellard; Ewan R. Pearson; Andrew T. Hattersley; Coralie Bingham


Book ID
114463866
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
380 KB
Volume
40
Category
Article
ISSN
0272-6386

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One form of maturity-onset diabetes of the young, Type 3 (MODY3), results from mutations in the gene coding for hepatocyte nuclear factor-1␣ (HNF-1␣), a transcription factor first described in the liver. MODY3 is characterized by a defective glucosestimulated insulin secretion. Earlier observations