Severe functional impairment and elevated PD-1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infection

Increased PD-L1 expression and PD-L1/CD8

Increased PD-L1 expression and PD-L1/CD86 ratio on dendritic cells were associated with impaired dendritic cells function in HCV infection

✍ Tao Shen; Xiangmei Chen; Yu Chen; Qiang Xu; Fengmin Lu; Shuang Liu 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 283 KB

## Abstract Impaired hepatitis C virus (HCV)‐specific T cell immunity was associated with the persistence of HCV infection. Dysfunction of dentritic cells (DCs) was believed to be involved in T cell exhaustion, but the mechanisms were rarely understood. In this study, surface costimulatory marker (