Severe exacerbation of liver disease during pregnancy in a thalassemic GBV-C/HGV-positive patient and neonatal hepatitis in offspring
✍ Scribed by Horsmans, Y.; Karayiannis, P.; Christophe, J.L.; Pickering, J.M.; Debauche, C.; Cornu, C.; Rahier, J.; Hess, G.; Thomas, H.C.; Geubel, A.P.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 239 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
The case of a young woman with GB virus C/hepatitis G virus (GBV-C/HGV) infection and with a severe exacerbation of chronic hepatitis of unknown etiology during pregnancy is described. In the offspring, severe neonatal hepatitis with subsequent mild chronic liver disease of at least 16-month duration was followed by the development of antibodies to the envelope protein (E2) of GBV-C/HGV, suggesting that the child was recovering from GBV-C/HGV infection. There was an improvement in clinical and biochemical parameters in the mother following delivery and alpha-interferon therapy was associated with a transient biochemical response.