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Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice

✍ Scribed by Vijay R More, Xia Wen, Paul E Thomas, Lauren M Aleksunes…

Book ID: 120689257
Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 622 KB
Volume: 11
Category: Article
ISSN: 1476-5926
DOI: 10.1186/1476-5926-11-1

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## Abstract TRB3 (a mammalian homolog of __Drosophila__) is emerging as an important player in the regulation of insulin signaling. TRB3 can directly bind to Ser/Thr protein kinase Akt, the major downstream kinase of insulin signaling. Conversely, physical exercise has been linked to improved gluco