Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency
β Scribed by Leonard D. Shultz; Thiruchandurai V. Rajan; Dale L. Greiner
- Book ID
- 114152876
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 771 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-7799
No coin nor oath required. For personal study only.
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We have previously shown that the SH2 domain-containing protein tyrosine phosphatase SHP-1 plays a critical role in controlling virus infection in CNS glia in vivo and in vitro. The present study addressed whether increased virus replication in SHP-1-deficient glia in vitro may be a result of altere
CD5, a membrane-associated glycoprotein, has been shown to negatively regulate antigen receptor-mediated growth responses in peritoneal B lymphocytes, thymocytes and mature T cells. The CD5-expressing peritoneal B cells (B-1) that are normally unresponsive to B cell receptor (BCR)-mediated growth si