Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam
✍ Scribed by Ha Vinh; Nguyen Ngoc Huong; Tran Thi Bich Ha; Bui Minh Cuong; Nguyen Hoan Phu; Tran Thi Hong Chau; Phan Tan Quoi; Keith Arnold; Tran Tinh Hien
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 391 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0035-9203
No coin nor oath required. For personal study only.
✦ Synopsis
One hundred and seventy five Viemamese adults with severe and complicated malaria admitted to a rural district hospital were entered into an open randomized comparative study to compare 4 treatment regimens based on artemisinin and its derivatives.The median time of defervescence was 48 h (95% confident interval [CI] 38-58 h) in those given intramuscular (i.m.) artemether, 42 h (95% CI 36-48 h) in those given arternisinin suppositories, 36 h (95% CI 30-42 h) in those receiving artesunate (i.m.) and 30 h (95% CI 18-42 h) in those receiving intravenous artesunate (eO.13). The respective median parasite clearance times were 30 h (95% CI 26-34 h), 30 h (95% CI 24-36 h), 24 h (95% CI 15-33 h), and 24 h (95% CI 15-33 h) (-0.30); the median times for recovery of consciousness were 47 h (95% CI 31-63 h), 24 h (95% CI 18-30 h), 30 h (95% CI 18-42 h), and 24 h (95% CI 4-44 h) eO.18); and the mortality rates were 1 l.l%, 17.6%, 10.2% and 16*6%, respectively eO.64).
There was no significant difference in efficacy between the 4 treatments.