𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Severe acute respiratory syndrome (SARS) coronavirus: application of monoclonal antibodies and development of an effective vaccine

✍ Scribed by Yasuko Tsunetsugu-Yokota; Kazuo Ohnishi; Toshitada Takemori

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
303 KB
Volume
16
Category
Article
ISSN
1052-9276

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

SARS‐CoV is a new type of human coronavirus identified as a causative agent of severe acute respiratory syndrome (SARS). On the occasion of the SARS outbreak, various monoclonal antibodies (mAbs) against SARS‐CoV have been developed and applied for diagnosis, clinical management and basic research. In this review, we overview the biochemical and functional properties and applications of these SARS‐CoV mAbs. We also focus on a variety of vaccines currently under development and discuss the immune response elicited by these vaccines in animal models, hopefully to better understand what we need to do next to fight against newly emerging pathogens in the future. Copyright © 2006 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Neutralizing human monoclonal antibodies
Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential
✍ Melissa M. Coughlin; Bellur S. Prabhakar 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 334 KB

## SUMMARY The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS‐CoV) led to a rapid response not only to contain the outbreak but also to identify possible therapeutic interventions, including the generation of human monoclonal antibodies (hmAbs). hmAbs may be used therapeutically w

Fusion core structure of the severe acut
Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): In search of potent SARS-CoV entry inhibitors
✍ Ling-Hon Matthew Chu; Siu-Hong Chan; Sau-Na Tsai; Yi Wang; Christopher Hon-Ki Ch 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 411 KB

## Abstract Severe acute respiratory coronavirus (SARS‐CoV) spike (S) glycoprotein fusion core consists of a six‐helix bundle with the three C‐terminal heptad repeat (HR2) helices packed against a central coiled‐coil of the other three N‐terminal heptad repeat (HR1) helices. Each of the three perip

Quantitative temporal-spatial distributi
Quantitative temporal-spatial distribution of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) in post-mortem tissues
✍ Julian W. Tang; Ka-Fai To; Anthony W.I. Lo; Joseph J.Y. Sung; H.K. Ng; Paul K.S. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB

## Abstract Few post‐mortem studies have been performed on patients who have died from severe acute respiratory syndrome (SARS). No studies have examined how the SARS‐associated coronavirus (SARS‐CoV) loads in different organs with respect to time, post‐mortem. The aim of this study was to determin