Severe 5-fluorouracil-related toxicity in a Japanese patient with dihydropyrimidine dehydrogenase deficiency
โ Scribed by T. Inada; Toko Jotsuka; Goro Matsuda; Hirofumi Kawakubo; Yoshiro Ogata; Tetsuro Kubota
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 55 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1341-9625
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๐ SIMILAR VOLUMES
Complete or partial loss of dihydropyrimidine dehydrogenase (DPD or DYPD) function has been described in cancer patients experiencing severe side effects upon administration of the fluoropyrimidine anticancer drug 5-fluorouracil (5-FU). To investigate a genetic predisposition for 5-FU intolerance du
## Abstract Cytotoxic effect of 5โfluorouracil 5โFU is mediated through inhibition of thymidylate synthase (TS), and 5โFU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5โFU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30
## Abstract ## Background. Some porphyrias are associated with cutaneous phototoxicity due to photoactivation of porphyrins, but whether ionizing radiation can have an additive effect is not clear. We report a case of severe radiation therapyโrelated toxicity in a patient with porphyria cutanea ta