Fused ring alkaloids having the pyrido[4,3,2-mnlacridine skeleton comprise a new class of marine natural products.laeh Their biological activityle and challenging structure elucidation make them an interesting group
Several new isoprenoids from two marine sponges of the family Axinellidae
β Scribed by Amira Rudi; Tesfamariam Yosief; Michael Schleyer; Yoel Kashman
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 872 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
β¦ Synopsis
Ten new isoprenoids have been isolated from two marine sponges Ptilocaulis spiculifer and Axinella weltneri. P. spiculifer afforded three triterpenes, dihydroyardenone (1), abudinol B (2), muzitone (3) and two Ct3 and CI7 metabolites of abudinol, nakorone (4) and durgarnone (5). A. weltneri gave five new sodwanones, N-R (6 -10). The structures of all new compounds were elucidated by spectroscopic analyses, mainly NMR data, and by chemical transformations to known compounds and degradations. The absolute configuration of several compounds was determined by optical measurements and comparison of the CD-eurves with those of several raspacionins. Several sodwanones were found to be cytotoxic.
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## Abstract A new 4βsulfated ceramide, ircisulfamide (=__N__β[(1__S__\*,2__S__\*,3__R__\*)β2βhydroxyβ1β(hydroxymethyl)β3β(sulfooxy)heptadecyl]hexadecanamide; **1**), and a new glycosphingolipid, ircicerebroside (=(2__R__\*)β__N__β{(1__S__\*,2__R__\*,3__E__,7__E__)β1β[(__Ξ²__βDβglucopyranosyloxy)meth