## Abstract α‐Aryl‐__o__‐xylyl dibromides **1** reacted with thioureas to give the mono‐isothiouronium salts **2**, bis‐isothiouronium salts **4** being formed as by‐products in some cases. Compounds **2**, which readily reacted with water or alcohols to form **3**, were cyclized with Na~2~CO~3~ in
✦ LIBER ✦
Seven-membered heterocycles. 9. Synthesis and properties of some 5-alkyl and 5-aryl derivatives of 1-benzothiepin
✍ Scribed by Traynelis, Vincent J.; Schield, John A.; Lindley, William A.; MacDowell, Denis W. H.
- Book ID
- 126230497
- Publisher
- American Chemical Society
- Year
- 1978
- Tongue
- English
- Weight
- 843 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-3263
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## Abstract A general method is described for the synthesis of 1‐aryl‐2‐alkyl‐1,4,5,6‐tetrahydropyrimidines 1, by cyclization of __N__‐acyl‐__N__′‐aryltrimethylenediamines 2 with trimethylsilyl polyphosphate. Precursors 2 were obtained by aminolysis of the corresponding __N__‐(3‐bromopropyl)amides