𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Set-shifting and behavioral dysfunction in primary focal dystonia

✍ Scribed by Paulo Bugalho; Bernardo Corrêa; João Guimarães; Miguel Xavier

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
73 KB
Volume
23
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The occurrence of cognitive and behavioral symptoms in patients with primary dystonia remains a matter of debate. We compared 45 patients with primary dystonia with 27 control subjects for performance on neuropsychological tasks with a load on executive‐Wisconsin Card Sorting Test (WCST) and Stroop test, and visuospatial‐Benton's visual retention test (BVRT) and Block assembly test from Wechsler Adult Intelligence Scale BAT‐functions, as well as for intensity of obsessive‐compulsive symptoms (Yale Brown Obsessive Compulsive Scale, Y‐BOCS). Correlation analysis was performed between neuropsychological performance, dystonia characteristics (duration, age of onset) and severity (Unified Dystonia Rating Scale, UDRS), and Y‐BOCS. Patients made more perseverative errors on the WCST (P = 0.042) and had a higher mean Y‐BOCS (P = 0.003) score than controls. Timed tests (BVRT, BAT, Stroop test) correlated with UDRS. Y‐BOCS, WCST, and UDRS scores were not significantly correlated with one another.These results suggest that patients with primary dystonia may have set‐shifting deficits and a higher intensity of obsessive compulsive symptoms when compared to healthy subjects. This may reflect a pattern of complex neurophysiological dysfunction involving dorsolateral, orbitofrontal, and motor frontostriatal circuits. © 2007 Movement Disorder Society

📜 SIMILAR VOLUMES

Facial recognition in primary focal dyst
Facial recognition in primary focal dystonia
✍ Martina Rinnerthaler; Cord Benecke; Lisa Bartha; Tanja Entner; Werner Poewe; Joe 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 70 KB

## Abstract The basal ganglia seem to be involved in emotional processing. Primary dystonia is a movement disorder considered to result from basal ganglia dysfunction, and the aim of the present study was to investigate emotion recognition in patients with primary focal dystonia. Thirty‐two patient

Strength deficits in primary focal hand
Strength deficits in primary focal hand dystonia
✍ Janey Prodoehl; Colum D. MacKinnon; Cynthia L. Comella; Daniel M. Corcos 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 157 KB

## Abstract Cortical activation is reduced when patients with focal dystonia perform movements that do not induce dystonic posturing. This finding suggests that the cortical drive to muscles may in some circumstances actually be reduced not increased, as suggested by basal ganglia models of dystoni

Obsessive-compulsive symptoms in primary
Obsessive-compulsive symptoms in primary focal dystonia: A controlled study
✍ Bernardo Barahona-Corrêa; Paulo Bugalho; João Guimarães; Miguel Xavier 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB

## Abstract Primary focal dystonia is an idiopathic neurological disorder causing involuntary muscle contraction. Its pathophysiology probably involves the basal ganglia and cortical‐basal pathways. Primary dystonia appears to be associated with significant obsessive‐compulsive symptoms, but eviden

Clinical and genetic evaluation in a Fre
Clinical and genetic evaluation in a French population presenting with primary focal dystonia
✍ Claire-Marie Dhaenens; Pierre Krystkowiak; Xavier Douay; Pierre Charpentier; Syl 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 57 KB

## Abstract Primary focal dystonia (PFD) is known to be a clinically and genetically heterogeneous group of movement disorders. To evaluate the frequency of familial focal dystonia in a French population presenting with PFD, we screened 197 patients (150 index cases and 47 affected family members)

Prevalence of primary late-onset focal d
Prevalence of primary late-onset focal dystonia in the Belgrade population
✍ Tatjana Pekmezović; Nataša Ivanović; Marina Svetel; Dragana Nalić; Tatjana Smilj 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 79 KB

## Abstract The aim of this cross‐sectional study was to estimate the prevalence of different subtypes of idiopathic focal dystonia in the population of Belgrade (Serbia), Yugoslavia. On December 31, 2001, the crude prevalence of all studied types of dystonia (focal, segmental, and multifocal) in B

Impaired intracortical inhibition in the
Impaired intracortical inhibition in the primary somatosensory cortex in focal hand dystonia
✍ Yohei Tamura; Masao Matsuhashi; Peter Lin; Bai Ou; Sherry Vorbach; Ryusuke Kakig 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB

## Abstract Somesthetic temporal discrimination (STD) is impaired in focal hand dystonia (FHD). We explored the electrophysiological correlate of the STD deficit to assess whether this is due to dysfunction of temporal inhibition in the somatosensory inhibitory pathway or due to dysfunction in stru