Session 7: Radionuclide Chemistry and Targetry

Session 7: Radionuclide production

📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 208 KB

## Introduction: The nuclide 225 Ac and its decay product 213 Bi have been identified as very suitable for targeted alpha-immuno-therapy [1]. First treatments of patients with acute myelogenous leukemia with a 213 Bi-labelled antibody HuM195 at Sloan Kettering Memorial Cancer Center, New York, pro

Session 2: Radionuclide production

📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 205 KB

## Aim In the recent years other -mostly metallic -radionuclides for PET gained more and more interest. However, for production of these alternative positron emitters the vast majority of them affords solid targets in form of metal foils, oxide or salt pellets [1, 2] which can not be operated by a

Session 7: Amyloid plaque

📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 191 KB

Session 4: PET chemistry

📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 201 KB

The prenyl group is known as an important structural building block in natural and medicinal products. The isotopic substitution of one of the two methyl groups with a [ 11 C]methyl group would provide an access to a large number of interesting 11 C-labelled compounds. Here we report a strategy for

Session 5: PET chemistry

📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 245 KB

18 F]fluorobenzyl halide derivatives are key intermediates for the synthesis of various radiopharmaceuticals such as 4-[ 18 F]fluoro-L-phenylalanine, 6-[ 18 F]fluoro-L-dopa or 2-[ 18 F]fluoro-Ltyrosine. These compounds are produced in our laboratory through a nca nucleophilic, multistep radiosynthe

Session 6: PET chemistry

📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 46 KB

Selenocysteine (Sec; U in one-letter code), the 21st amino acid existing in all selenoproteins, has unique biochemical properties due to its selenium atom, including a low pK a and a high reactivity with many electrophilic agents. Mammalian thioredoxin reductase (TrxR) is a selenoprotein with a redo