Introduction: Dendritic cells (DC) are professional antigen-presenting cells. In patients, DC can induce an effective antitumor response by presenting a tumor-derived peptide in the groove of major histocompatibility complexes (MHC) to naΓ―ve T-cells. In our ongoing clinical trials, HLA-A2.1 + melano
Session 10: Other
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- French
- Weight
- 84 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-2135
- DOI
- 10.1002/jlcr.977
No coin nor oath required. For personal study only.
β¦ Synopsis
Expression of HER2/neu antigen in breast cancer has well-documented prognostic and predictive values. There are evidences that diagnostically important information may be obtained by detection of HER2 expression in other carcinomas e.g. prostate cancer. The use of molecular imaging of HER2 expression can help to avoid false-negative biopsy results associated with sampling errors of heterogeneity of an antigen expression. A number of conjugates based on anti-HER2 antibodies and their fragments has been proposed and evaluated for non-invasive imaging of HER2-expression in vivo.
The goal of this study was to evaluate a labeling of anti-HER2 Affibody molecule Z HER2:342 with 111
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