Sesquiterpene synthesis. Studies relating to the synthesis of (.+-.)-dugesialactone
β Scribed by Zoretic, P. A.; Ferrari, J. L.; Bhakta, C.; Barcelos, F.; Branchaud, B.
- Book ID
- 127331696
- Publisher
- American Chemical Society
- Year
- 1982
- Tongue
- English
- Weight
- 423 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The pseudoguaianolides constitute a major family of sesquiterpenes, over thirty having been recorded to date. (1) They also afford a singular synthetic challenge in that most members (I) have six asymmetric centers, all grouped on a cycloheptane ring, with both cis-and trans-lactones being represent
Two approaches to the partial synthesis of C1-Cs of a bis-nor maytansinoid 1 have been investigated starting on the one hand with (S)-(-)-malic acid and on the other, with D-(+)-ribonolactone. 2 Maytansinoids are interesting naturally occurringIantitumor agents . 3 Extensive work has already been ca