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Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells

✍ Scribed by Tomoya Yokota; Youichirou Matsuzaki; Makoto Koyama; Toshiaki Hitomi; Mayumi Kawanaka; Masako Enoki-Konishi; Yusuke Okuyama; Junko Takayasu; Hoyoku Nishino; Akiyoshi Nishikawa; Toshihiko Osawa; Toshiyuki Sakai


Book ID
108583968
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
264 KB
Volume
98
Category
Article
ISSN
1347-9032

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Transforming growth factor-␀1 (TGF-␀1) inhibits cell growth in susceptible cells by interacting with a family of protein kinases that control cell cycle progression. In the present study, we investigated the effects of TGF-␀1 on cyclin D1 expression and activity in COLO-357 human pancreatic cancer c