Serum α-L-Fucosidase: A New Marker for the Diagnosis of Primary Hepatic Carcinoma?

✍ Scribed by Yves Deugnier; Véronique David; Pierre Brissot; Philippe Mabo; Damien Delamaire; Michel Messner; Michel Bourel; Jean-Yves Legall

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 376 KB
• Volume: 4
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840040516

✦ Synopsis

alpha-L-fucosidase, a lysosomal enzyme which catabolizes fucoproteins, was studied in sera from 30 controls, 32 patients with primary hepatic carcinomas, 24 patients with secondary metastatic liver carcinomas and 36 patients with cirrhosis. Serum alpha-L-fucosidase was increased in primary hepatic carcinomas (145.5 +/- 12 nkat per liter) with a high statistical significance versus controls (51.4 +/- 4.5 - p less than 10(-7], secondary metastatic liver carcinomas (58.9 +/- 6.4 - p less than 10(-5] and cirrhotics (71.3 +/- 6 - p less than 10(-5). A level exceeding 110 was a useful marker for the diagnosis of primary hepatic carcinoma with 75% sensitivity and 90% specificity.