✦ LIBER ✦

Serum vitamin B12-binding proteins in a case of eosinophilic leukemia

✍ Scribed by Coltman, Charles A. ;Panettiere, Frank ;Carmel, Ralph

Publisher: John Wiley and Sons
Year: 1975
Tongue: English
Weight: 463 KB
Volume: 1
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950010302

No coin nor oath required. For personal study only.

✦ Synopsis

A patient with subacute eosinophilic leukemia is presented, with full recognition of the controversy surrounding that entity. Serum vitamin B12 and B12-binding protein studies and simultaneous complete blood counts were done before and during 6 months of high-dose, intermittent combination chemotherapy. The patient presented with extremely high levels of serum vitamin B12, unsaturated B12-binding capacity, and transcobalamin I, all of which resembled the highest values seen in chronic myelogenous leukemia. Serial studies, during and after remission induction, showed a precipitous fall of serum vitamin B12 and unsaturated B12-binding capacity to normal levels. The data show that transcobalamin I levels, which eventually reached low-normal range, correlate best with the level of circulating and bone marrow eosinophils. Transcobalamin II and serum third binder appeared to be normal throughout the patient's course. The B12-binding protein abnormalities are not considered diagnostic of eosinophilic leukemia.

📜 SIMILAR VOLUMES

Serum homocysteine, folate, vitamin B12

Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis?

✍ M. Shargorodsky; M. Boaz; S. Pasternak; R. Hanah; Z. Matas; A. Fux; Y. Beigel; M 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 105 KB

Plasma C-peptide, insulin-like growth fa

Plasma C-peptide, insulin-like growth factor-I, insulin-like growth factor binding proteins and risk of colorectal cancer in a nested case-control study: The Japan public health center-based prospective study

✍ Tetsuya Otani; Motoki Iwasaki; Shizuka Sasazuki; Manami Inoue; Shoichiro Tsugane 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 92 KB 👁 1 views

## Abstract The physical inactivity and obesity involved in hyperglycemia and hyperinsulinemia is supposed to lead to an increased bioavailability of insulin‐like growth factor‐I (IGF‐I). The carcinogenic effect of IGF‐I may be influenced by IGF binding proteins. We investigated the association bet