Serum trace elements in animal models and human depression. Part I. Zinc

✍ Scribed by Gabriel Nowak; Andrzej Ziȩba; Dominika Dudek; Miroslaw Krośniak; Maria Szymaczek; Malgorzata Schlegel-Zawadzka

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 77 KB
• Volume: 14
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/(sici)1099-1077(199903)14:2<83::aid-hup74>3.0.co;2-6

✦ Synopsis

In the present study we report the results of investigations into the serum zinc levels in a clinical study of 19 patients with unipolar depression; 16 normal controls and in three animal models of depression: chronic severe stress (CSS), chronic mild stress (CMS) and olfactory bulbectomy (OB) in rats. CSS model and unipolar depressed patients exhibit lower serum zinc levels than the appropriate controls. There was no eect on the value in CMS or OB models. The present ®ndings con®rm previous clinical data indicating decreased serum zinc levels in human depression. Moreover, the data indicate that dierences exists in the serum zinc levels in dierent animal models of depression and suggest a similarity between the CSS model and human depression with regard to this marker.