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Serum Thyrotropin responses to Thyrotropin-Releasing Hormone in medium- and long-term abstinent alcohol dependent patients

✍ Scribed by M. O’Hanlon; D. Scull; S. Whitehouse; A. Kahn; T. G. Dinan

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 347 KB
Volume: 11
Category: Article
ISSN: 0885-6222
DOI: 10.1002/(sici)1099-1077(199601)11:1<33::aid-hup741>3.0.co;2-k

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✦ Synopsis

Twenty-three euthymic alcoholics in medium-and long-term abstinence were studied as were 20 healthy controls. All underwent a Thyrotropin Releasing Hormone/Thyrotropin Stimulating Hormone (TRH/TSH) stimulation test. Ninety per cent of medium-term abstinent and 100 per cent of long-term abstinent alcoholics had a response within the normal range. However, overall, the TSH responses to TRH were significantly less than in controls. Our study suggests that while there is some improvement in TRH/TSH responses in long-term abstinent patients, there is still evidence of hypo function in those over 1 year alcohol-free.

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