𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Serum theophylline analysis by isotope dilution mass spectrometry

✍ Scribed by Monica Culea; Nicolae Palibroda; Maria Chiriac; Zaharie Moldovan

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
213 KB
Volume
19
Category
Article
ISSN
1076-5174

No coin nor oath required. For personal study only.

✦ Synopsis

Serum theophylline analysis was attempted using stable isotope dilution mass spectrometry. Theophylline "Nlabelled in position 7 was used as internal standard. The analysis was performed at resolution 3OOO by selected ion monitoring with temperature programming. The sample was introduced in underivatized form by means of the direct inlet probe. Good linearity was obtained in the concentration range 5-40 pg ml-' with relative standard deviations less than 6%. The method is simple and permits six samples to be run per hour. Sensitivity permits analysis at 0.5 pg ml-' at a signal to noise ratio 4: 1.

πŸ“œ SIMILAR VOLUMES

Memory effects in combining isotope rati
Memory effects in combining isotope ratio monitoring with isotope dilution mass spectrometry
✍ Gunther Dube; AndrΓ© Henrion; RΓΌdiger Ohlendorf πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 35 KB πŸ‘ 1 views

Combining isotope ratio monitoring with isotope dilution techniques provides very accurate results in the quantitative analysis of volatile organic chemical compounds by gas chromatography/mass spectrometry (GC/MS). However, this method requires that spikes highly enriched in 13 C be used. This may