Serum sex-hormone-binding globulin is related to hepatic and peripheral insulin sensitivity but not to beta-cell function in men and women with Type 2 diabetes mellitus
✍ Scribed by Laing, I.; Olukoga, A.O.; Gordon, C.; Boulton, A.J.M.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 69 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0742-3071
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✦ Synopsis
This study examined the relationship of hepatic and peripheral insulin sensitivity and cell secretory function with serum sex hormone-binding globulin (SHBG) in men and women with Type 2 diabetes mellitus (DM). Fasting insulin, glucose and SHBG were measured in 58 Type 2 diabetic patients of both sexes (36 men) who were on diet treatment only and terms for insulin sensitivity and -cell secretion obtained by modelling. There was no significant difference in SHBG between men and women despite similar degree of obesity. SHBG was positively correlated (r ؍ 0.41, p Ͻ 0.01) to hepatic insulin sensitivity derived from mathematical modelling of fasting glucose and insulin data using the homeostasis assessment model (HOMA). This relationship was independent of gender (men, r ؍ 0.48, p Ͻ 0.01; women, r ؍ 0.45, p Ͻ 0.05). Fasting insulin correlated negatively with SHBG in men (r = -0.34, p Ͻ 0.05). There were also significant negative correlations between SHBG and either plasma glucose (r ؍ ؊0.29, p Ͻ 0.05) or body mass index (r ؍ ؊0.34, p Ͻ 0.05). SHBG did not correlate with HOMA-modelled beta-cell function. In a multiple regression analysis, SHBG was independently correlated only with insulin sensitivity (p Ͻ 0.05). Further studies in 15 of the diabetic patients (11 men), showed a significant positive correlation (r ؍ 0.52, p Ͻ 0.05) between SHBG and peripheral insulin sensitivity derived by continuous infusion of glucose with model assessment (CIGMA) but not between SHBG and CIGMA-modelled -cell function. These results indicate that both hepatic and peripheral insulin sensitivity are similarly related to serum SHBG in Type 2 diabetes of both sexes. The sex-difference in SHBG was abolished in the patients.