𝔖 Bobbio Scriptorium
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Serum ribonuclease in patients with lung carcinoma

✍ Scribed by Patrick C. Marabella; George L. Tritsch; Robert H. Moore; Hiroshi Takita

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
250 KB
Volume
8
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Fifty‐one previously untreated cases of lung carcinoma and 7 normal healthy controls were evaluated with respect to serum ribonuclease (S‐RNase) levels. Cellular immunity was tested in 22 of these 51 cases by leukocyte migration inhibition test (MIT) using extract of culture cell line of lung carcinoma.

S‐RNase levels in lung carcinomas were significantly elevated. There appeared to be no difference in S‐RNase levels by histological classification. More striking was high S‐RNase level in disseminated versus localized cases. MIT results indicated impairment of cellular immunity in those cases of more elevated S‐RNase. S‐RNase may be implicated in blocking phenomenon associated with neoplastic disease.

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