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Serum pregnancy-associated α2-glycoprotein levels in the evolution of Hepatitis B virus infection

✍ Scribed by Jorge A. Zarzur; Mario Aldao; Santos Sileoni; Miguel A. Vides

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
430 KB
Volume
3
Category
Article
ISSN
0887-8013

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✦ Synopsis

Serum pregnancy-associated a2-glycoprotein (a2-PAG) levels were evaluated in a follow-up study of patients with hepatitis B virus (HBV) infection and compared with biochemical and virological parameters. In a study of 25 patients with acute hepatitis, an association was found between high a2- PAG values, ALT levels, and HB,Ag in 20 patients (80%) (P <0.05), 18 recovered completely, and 2 had a protracted course. In five patients serum a2-PAG levels were similar to those in the control group. On the other hand, eight (100%) chronic per-sistent HEW patients showed high levels of a2-PAG (P < 0.05) during the study period, and these levels correlated well with inflammatory activity and failure of HB,Ag elimination. There were no significant differences in a2-PAG values between asymptomatic HB,Ag carriers and controls.

Serial analysis of a2-PAG, in correlation with viral markers, biochemical parameters, and histological data, would contribute to the ability to predict the final outcome of HBV infection.

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