Serum pepsinogen i in rheumatic diseases. reduced levels in sjögren's syndrome

✍ Scribed by C. Peter J. Maury; VESA Räsänen; Anna-Maija Teppo; Tapani Helve; Otto Wegelius

• Book ID: 101645996
• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 393 KB
• Volume: 25
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780250905

✦ Synopsis

Abstract

Group I pepsinogens were measured by radioimmunoassay in the sera of 93 patients with rheumatic diseases and 99 controls. Patients with rheumatoid arthritis and systemic lupus erythematosus had levels of pepsinogen I similar to controls, whereas patients with Sjögren's syndrome had levels significantly lower than either controls (P<0.001) or patients with rheumatic diseases not associated with sicca syndrome (P<0.001). The concentrations of serum pepsinogen I were lower in patients with sicca syndrome alone than in those with sicca syndrome associated with some other connective tissue disease (P<0.05). In patients with Sjögren's syndrome, a negative correlation was found between serum concentrations of β~2~‐microglobulin and pepsinogen I (r = −0.46, P<0.05).