Serum markers for type IV collagen and type III procollagen in the myelofibrosis-osteomyelosclerosis syndrome and other chronic myeloproliferative disorders

Hepatic fibrosis in rats produced by car

Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: Observations suggesting immunoassays of serum for the 75 fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal propeptide of type III procollagen

✍ Leena Ala-Kokko; Volkmar Günzler; Jan B. Hoek; Emanuel Rubin; Darwin J. Prockop 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 567 KB

Liver fibrosis was induced in rats both with carbon tetrachloride and dimethylnitrosamine. Assays were performed on steady-state levels of messenger RNAs in the liver for several collagens and basement membrane components. The results indicated marked increases in the steady-state levels of messenge