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Serum lipoproteins of rats bearing transplanted morris hepatoma 7777

✍ Scribed by K. Ananth Narayan; Harold P. Morris

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
413 KB
Volume
5
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The serum lipoprotein patterns of Buffalo‐strain rats bearing hepatoma 7777 were determined in the 2nd, 4th and 5th weeks after transplantation of the tumor. The result indicated the presence of a slow‐moving HDL component which was similar to that observed previously in Holtzman rats given 0.03% N‐2‐fluorenylacetamide. Five weeks after transplantation of the tumor, the serum lipoproteins were isolated ultracentrifugally and quantified by chemical analyses and by disc electrophoresis using a protein stain. These results have confirmed the increase in serum lipoproteins, especially the high density lipoprotein, HDL~2~, in these tumor‐bearing rats. The serum total lipid, cholesterol and phospholipid were considerably increased while the total serum proteins were only slightly elevated in rats with tumors as compared to control rats. A new α~1~‐globulin component was observed in the serum protein patterns in the tumor‐bearing rats.

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