Serum levels of insulin-like growth factor 1 in subjects with osteoarthritis of the knee. Data from the baltimore longitudinal study of aging

✍ Scribed by Marc C. Hochberg; Margaret Lethbridge-Cejku; William W. Scott Jr.; Ralph Reichle; Chris C. Plato; Jordan D. Tobin

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 383 KB
• Volume: 37
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780370811

✦ Synopsis

To examine the relationship between serum levels of insulin-like growth factor 1 (IGF-1) and osteoarthritis (OA) of the knee.

Methods. Serum IGF-1 levels were compared in 162 male and 101 female subjects age 220 stratified by presence of radiographic changes of OA of the knee.

Results. Mean serum IGF-1 levels were significantly lower in subjects with knee OA; however, after adjustment for age-related changes in IGF-1 levels, these differences were no longer significant.

Conclusion. These data fail to support the hypothesis that serum IGF-1 levels are reduced in subjects with OA of the knee independent of the known age-related changes in these levels.

Insulin-like growth factor 1 (IGF-1), a mediator of the effects of growth hormone at the local tissue level (l), has been shown to enhance chondrocyte proliferation and proteoglycan and collagen synthesis by chondrocytes in normal cartilage in vitro (2-1 l), as well as to inhibit cytokine-stimulated degradation of proteoglycans in normal cartilage in vitro (12,13).