Serum levels of C1q, C1r and C1s in normal and pathologic sera

✍ Scribed by María M de E de Bracco; Jorge A Manni

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 498 KB
• Volume: 17
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780170204

✦ Synopsis

Abstract

C1q, C1r and C1s protein concentrations were simultaneously assayed in sera of patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, autoimmune hemolytic anemia, and viral hemorrhagic fever as well as in healthy adult control subjects. Correlation coefficients between the three subunits of C1 were calculated and the sequential evolution of C1q, C1r, and C1s levels was studied in patients with SLE. In the majority of cases there was a good correlation between C1q, C1r, and C1s; subunit levels increased or decreased in a coordinated fashion. A marked discrepancy between C1q, C1r, and C1s serum concentration was observed in 3 instances. Low C1q coexisted with extremely high C1r and C1s values. It appears that C1r and C1s are closely linked while C1q may vary in a more independent way.