## Abstract Weight loss is a common problem in Parkinson's disease (PD), but the causative mechanisms behind this weight loss are unclear. We compared 26 PD patients with sex and age matched healthy controls. Examinations were repeated at baseline, after one and after two years. Body fat mass was m
Serum leptin concentrations and satiety in Parkinson's disease patients with and without weight loss
β Scribed by Virgilio G.H. Evidente; John N. Caviness; Charles H. Adler; Katrina A. Gwinn-Hardy; Richard E. Pratley
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 25 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.1165
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
We compared serum leptin and satiety measures in 18 Parkinson's disease (PD) patients with unintended weight loss (WL) and 18 PD patients whose weight was stable (WS). Mean serum leptin concentrations tended to be lower in WL than WS patients, but this did not reach statistical significance. Body mass index correlated with serum leptin concentrations. Ratings of hunger, satiety, fullness, and thirst did not differ between groups. However, the mean sensation of fullness before meals correlated with serum leptin in the entire cohort of patients, particularly in the WL group. The results indicate that unintended weight loss in PD patients is unlikely to be due to abnormal serum leptin concentrations. Β© 2001 Movement Disorder Society.
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