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Serum hyperglycosylated hCG: a potential screening test for fetal Down syndrome

โœ Scribed by Shohreh Shahabi; Utku A. Oz; Ray O. Bahado-Singh; Maurice J. Mahoney; Aziza Omrani; Alexander Baumgarten; Laurence A. Cole

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
111 KB
Volume
19
Category
Article
ISSN
0197-3851

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โœฆ Synopsis

correctly normalize urine data. The tighter distribution of hyperglycosylated hCG measurements in serum may compensate for the lesser elevation of values in Down syndrome cases. Hyperglycosylated hCG determinations might be equally useful in urine and serum samples. 60 per cent sensitivity is suggested with as little as 1.5 per cent false-positive rate. It might be possible to combine serum hyperglycosylated hCG with established serum markers to achieve higher detection rates. Hyperglycosylated hCG measurements could, for instance, replace or supplement regular hCG in the serum triple-screen test. Larger studies are now needed to confirm these preliminary observations.

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