𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Serum hyaluronate in primary biliary cirrhosis—A biochemical marker for progressive liver damage

✍ Scribed by Anders Nyberg; Anna Engström-Làurent; Lars Lööf

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
514 KB
Volume
8
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

To evaluate serum hyaluronate as a marker for progressive liver injury in patients with primary biliary cirrhosis, a longitudinal study including 48 patients was conducted with a mean follow-up time of 40 months. The patients were examined every 6 months with a standardized set of conventional liver function tests, and a liver biopsy was performed every year. The hyaluronate concentration correlated significantly (p c 0.001) with albumin, t% galactose tolerance test, bilirubin and prothrombin time but not to serum variables reflecting inflammatory activity. Furthermore, there was a close correlation between serum hyaluronate levels and histopathological changes in the liver. The hyaluronate concentration increased significantly over time in all clinical stages of primary biliary cirrhosis (p < 0.01), whereas the conventional liver function tests only changed in the advanced cases. The present data indicate that serum hyaluronate may be a sensitive marker for progressive liver damage in primary biliary cirrhosis. Serial determinations of hyaluronate are therefore of potential value for monitoring liver function during clinical management of the condition.

📜 SIMILAR VOLUMES

Antimitochondrial antibodies in acute li
Antimitochondrial antibodies in acute liver failure: Implications for primary biliary cirrhosis
✍ Patrick S. C. Leung; Lorenzo Rossaro; Paul A. Davis; Ogyi Park; Atsushi Tanaka; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 2 views

In our previous work, including analysis of more than 10,000 sera from control patients and patients with a variety of liver diseases, we have demonstrated that with the use of recombinant autoantigens, antimitochondrial autoantibodies (AMAs) are only found in primary biliary cirrhosis (PBC) and tha

Prediction of clinical outcomes in prima
Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay
✍ Marlyn J. Mayo; Julie Parkes; Beverley Adams-Huet; Burton Combes; A. S. Mills; R 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 241 KB 👁 1 views

Primary biliary cirrhosis (PBC) is sometimes diagnosed based on a positive antimitochondrial antibody in the appropriate clinical setting without a liver biopsy. Although a liver biopsy can assess the extent of liver fibrosis and provide prognostic information, serum fibrosis markers avoid biopsy co

High cholestanol and low campesterol-to-
High cholestanol and low campesterol-to-sitosterol ratio in serum of patients with primary biliary cirrhosis before liver transplantation
✍ Katriina Nikkilä; Krister Höckerstedt; Prof. Tatu A. Miettinen 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 693 KB

Serum levels of cholesterol precursors (squalene, A8-cholestenol, desmosterol and lathosterol), plant sterols (campesterol and sitosterol), cholestanol and cholestanol/noncholesterol sterol ratios were related to liver damage and liver transplantation indications in healthy controls (n = 26) and in

The human hepatic asialoglycoprotein rec
The human hepatic asialoglycoprotein receptor is a target antigen for liver-infiltrating T cells in autoimmune chronic active hepatitis and primary biliary cirrhosis
✍ Hanns Löhr; Ulrich Treichel; Thomas Poralla; Michael Manns; Prof. Dr. Dr. Karl-H 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 724 KB

Autoantibodies to the human hepatic asialoglycoprotein receptor have been found in nearly 50% of the sera of patients with autoimmune chronic active hepatitis and in 15% of patients with primary biliary cirrhosis. In this study we demonstrate that the human hepatic asialoglycoprotein receptor is als